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Indeed, although our screen indicates a decrease in total cell count upon treatment, suggesting a cytotoxic effect, there was limited change to variant distribution, suggesting that there was a global decrease in the population rather than a specific sub-population of sensitive mutants

10.1016/j.jsps.2012.05.002 5 AmoratiR.ValgimigliL

16 This treatment scheme varied from those previously published in mice in terms of treatment duration

It can fade superficial tanning by cleansing and exfoliation, but the results are slow