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Although ROS generation may not be an essential factor for aging (Lpez-Otn et al., 2013), they are more likely to exacerbate age-related diseases progression via oxidative damage and interaction with mitochondria (Dias et al., 2013)

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Other outcomes In a follow-up evaluation of the KIHD study, a combination of high CRF levels and frequent sauna baths was demonstrated to be associated with a substantially lowered risk of incident pneumonia compared with each modality alone [69]