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S., & Cha, H

Hickey AJ, Chai CC, Choong SY, et al

Circulation 123 , 1322 (2011)

By combining Reverse Transcriptase inhibitors plus protease inhibitors, synergism was obtained and the amounts of viral particles in the plasma plummeted, while the speed of the developing mutant resistant viral strains was slowed, compared to using only one type of inhibitor