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Our results extend this understanding by showing that conjugated primary and secondary BAs are associated with mental health outcomes

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One critical safety note: glutathione depletes zinc and selenium over prolonged high-dose use because it relies on these minerals as cofactors for glutathione peroxidase and glutathione reductase enzymes

Ma QL, Zhu C, Morselli M (2020) The novel omega-6 fatty acid docosapentaenoic acid positively modulates brain innate immune response for resolving neuroinflammation at early and late stages of humanized APOE-based Alzheimers disease models

Moreover, in models of ischemiareperfusion injury and in KEAP1-inactivated lung cancer, inhibition or genetic ablation of CoQ biosynthetic enzymes restored sensitivity to ferroptosis or radiotherapy 115,116 , underscoring the reliance of some cancer cells on an abundant CoQ pool for redox defense and survival