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Through comparative analysis of three geographically diverse gut metabolomic datasets (four case-control comparison) encompassing IBD cohorts and non-IBD controls (including patients with varying disease activity states), we identified significant pathway enrichment in aromatic amino acid metabolism, particularly involving tyrosine, phenylalanine, and tryptophan catabolism (Fig

This is consistent with the hypothesis that before the Adh1-Adh2 duplication, yeast did not accumulate ethanol for later consumption but rather used Adh A to recycle NADH generated in the glycolytic pathway