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Subsequent studies focused on the structural modification of 27 afforded a new synthetic triterpenoid inhibitor 2-cyano-3,12-dioxooleana-1,9,-dien-28-oic acid imidazolide ( 28 ) [147]

doi: 10.3389/fimmu.2014.00071

For example, S.aureus triggers an inflammatory phenotype of keratinocytes with inflammatory cytokine release, inflammasome activation and AMP production, also causing keratinocyte death [55]