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More significant weight loss typically occurred over several months, with results continuing to improve over time when combined with semaglutide

Citations Citations and reference data

Bendinelli P, Maroni P, Matteucci E, Desiderio MA

Indeed, in pre-clinical models, retatrutide, a triple agonist (GLP-1/GIP/glucagon), resulted in greater WL and improved glucose profile compared to tirzepatide through increased energy expenditure and reduced calorie intake [80, 81]