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Figure 1 Oxidative stress OS refers to the imbalance of pro-oxidants and antioxidants and the disruption of redox signaling and control ( Radiotherapy-induced oxidative stress Oxidative stress and ROS may be the main cause of ionizing radiation (IR)-induced cardiotoxicity ( Myocardial fibrosis is a late manifestation of radiation-induced heart disease (RIHD) (50)

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Two modes of action of the histone hyperacetylation have been proposed and are not mutually exclusive

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