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In addition, the ROS produced by ATMs first affect their recruitment and polarization, especially in cases such as diabetes, ROS induces ATMs to polarize towards M1 and the release of inflammatory factors (145, 146)

Tumor necrosis factor (TNF- ), interferon (IFN- ), and interleukins such as IL-6 and IL-1 have been reported to cause the failure of the BBB

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Thanks to my really helpful GP she also investigated why the fatigue hadnt eased as expected and found I also had a heart condition