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Early studies revealed that ATO promotes degradation of the oncogenic PML-RAR fusion proteins by directly binding to cysteines in the zinc fingers of the N-terminal RING domain of PML and PML-RAR, resulting in oligomerization, leading to enhanced SUMOylation, ubiquitination and subsequent degradation (Fig

Genome-wide methylation profiles reveal quantitative views of human aging rates

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Recently, it has been shown that increased uptake of DA through the DAT in mice results in oxidative damage, neuronal loss and motor deficits (Masoud et al., 2015)