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In contrast, another metabolomic study of tracheal aspirates from infants 28 weeks gestation noted that early decreases in fatty-acid metabolism, particularly the fatty acid -oxidation pathway, may predispose infants to developing BPD 46

9 Conversely, hypothyroidism suppresses metabolic rate and can result in weight gain, dyslipidemia, cold intolerance, depression, fatigue, and hyporeflexia

In animal models, both a short photoperiod (5 hours a day) and constant light exposure during the day, physiological sleeping period, may lead to impaired glucose tolerance and the absence of rhythmicity in insulin sensitivity, respectively [94,95]

Epigenetic resetting in the human germ line entails histone modification remodeling