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With the rise of Arabidopsis as a study system, and notably genome sequencing, the pathway and its genes were characterized at the molecular genetic level, revealing (or confirming) that all four enzymes were encoded by more than one gene, thus explaining the presence of the enzyme activities in several compartments (Table 1)

doi: 10.1016/j.tplants.2006.07.002 66 LvY.ZhaoY.HeY.WangJ.ZhengY.ChenX.et al

Mente A, Chalcraft K, Ak H, et al

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Specifically, fructose increased the activity of LAMP2A and TFEB, changes that are associated with altered expression of genes involved in the ferroptosis pathway, potentially enhancing the malignant characteristics of ovarian cancer stem cells (22)