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Depletion of GSH promotes or enhances oxidative stress 9 , inflammatory cytokine levels 10 , and radiation-induced cell damage 11

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These responses may include mild fatigue, changes in bowel patterns, or minor skin changes as the body increases its detoxification activity

The ability of mitochondria to rapidly adapt to stress, including stress imposed by antimetabolites such as 5FU, means that they have significant potential to dictate therapeutic responses 11

Time course and magnitude of alpha-synuclein inclusion formation and nigrostriatal degeneration in the rat model of synucleinopathy triggered by intrastriatal -synuclein preformed fibrils