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In vivo, in vitro, and in silico analyses of HIF-1 structure and function indicate that marine mammal HIF-1 stabilization is highly sensitive to hypoxia [49,50,51,52,53]

sgRNA complexes are synthesized by mixing equal volumes of crRNA (2 L, 160 M in nuclease free water) and tracrRNA (2 L, 160 M) and are incubated at 37 C for 30 min before Cas9 (2.7 L, 10 g/L, Alt-R S.p

Elgendy, M

In addition to the classical ferroptosis pathway with GPX4 as the core described by Stockwell, some studies also proposed GPX4-independent pathways, such as ferroptosis regulated by p53 ( Figure 1 2.1 Important process of ferroptosis 2.1.1 Iron accumulation Ferric ions (Fe 3+ ) bind to transferrin (TF) in the blood circulation and the complex can then be transferred into the endosomes inside the cells via transferrin receptor 1 (TfR1) on the cell membrane

Ann Surg 261(6):1114-23, 2015