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Description

Gastroenterology 2009

Sepsis-induced acute kidney injury (S-AKI) occurs within 7 days of the onset of sepsis, and is extremely common in the intensive care units (ICU), being present in approximately half of the patients with acute kidney injury (AKI) in this environment (2)

FSP1 catalyzes the reduction of CoQ10 to CoQ10H 2 , a lipophilic antioxidant that neutralizes PL-OOHs and halts lipid peroxidation, thereby suppressing ferroptosis independently of GPX4 ( 2 that scavenges ROS and phospholipid hydroperoxides (PL-OOHs) within mitochondria and prevents ferroptosis (Mao et al., 2021