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GLP-1 receptor activation The GLP-1 component of retatrutide reduces appetite through multiple mechanisms: slowing gastric emptying (food stays in your stomach longer, so you feel full sooner), signaling satiety centers in the brain (your brain gets a stronger "stop eating" signal), and enhancing insulin secretion in response to meals

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72 For example, the elimination rate constant of theophylline is less in cats (0.089/hr) 73 than dogs (0.12/hr), resulting in a longer half-life in the cat (7.8 hours) compared with the dog (5.7 hours), 64, 65 thus necessitating a smaller dose in cats