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Transcriptomic analyses following short-term exposure to cisplatin or EGFR-targeted therapies revealed that early DTP cells rapidly acquire non-proliferative, stress-adaptive transcriptional programs, including alterations in chromatin-associated regulators, metabolic pathways, and survival-related genes

On one hand, excess unstable -globin chains bind with heme to form haemichromes that are deposited in the erythroblasts membrane

doi: 10.1007/s00018-020-03679-5 252 ReedAIchuT-AMilosevichNMelilloBSchafrothMAOtsukaYet al

The contribution of these two enzymes in response to the increasing ROS concentration is very important