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J Gastroint Oncol

El-Serag 1 and Fasiha Kanwal 1 , (1)Baylor College of Medicine, (2)Icahn School of Medicine at Mount Sinai Background: Informal caregivers of patients with chronic liver disease could experience significant burden from caregiving with negative consequences for caregivers and patients outcomes

Diarrhea, abdominal cramps, and constipation have been reported

Traditional Chinese medicine (TCM) has received extensive attention because of its advantages including minimal adverse reactions, multiple targets, and effectiveness through multiple pathways

Therefore, introducing drug development technologies, such as computer-aided drug design, high-throughput screening, systems modeling and simulation to obtain derivatives of AS-IV with increased bioavailability and conducting targeted validation or further adopting biocompatible drug carriers, such as nanoparticles, liposomes and micelles encapsulating AS-IV, may be required to achieve its efficient delivery