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This preclinical proof-of-concept study shows that RG7774 is a novel, highly selective, and orally bioavailable cannabinoid 2 receptor (CB2R) agonist, with a favorable systemic and ocular pharmacokinetic profile, and beneficial effects on vascular permeability, leukocyte adhesion, and ocular inflammation (key pathological features of DR) in animal models of retinal disease

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