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doi: 10.1038/s41556-018-0178-0

In MDD, retrospectively evaluated ACEs are strongly correlated with heightened IRS activity, T-cell activation, Th1 and M1 polarization, immune-linked neurotoxicity, decreased CIRS activation and Teg cells, IRS sensitization, lipid peroxidation, protein oxidation, diminished antioxidant defenses, and gut dysbiosis