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The integration of creatine biomarkers with digital health tools, wearable biosensors, and adaptive dosing algorithms could further enhance personalization and patient engagement in preventive care

It can shape a profoundly immunosuppressive TME by inducing the expansion of myeloid cells, enhancing the suppressive function of Tregs, or directly driving CD8 + T cells toward terminal exhaustion, thereby undermining the efficacy of various immunotherapies [292,293,294,295,296]

A deficiency in B12 can lead to feelings of irritability, anxiety, and even depression

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This, in turn, enhances the drug efficacy while reducing the risk of systemic toxicity, as it helps prevent rapid burst release and minimizes the need for repeated dosing (Natarajan et al., 2014