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An increasing number of studies have documented that failed lysosomal function is closely related to the occurrence and development of neurodegenerative diseases, including Gaucher disease, hereditary spastic paraplegias, and Alzheimers disease (AD) 18,123,124,125

For instance, the ecotoxicity of silver varies significantly between metallic AgNPs and their sulfide-transformed forms (Ag 2 S), with reduced bioavailability and toxicity in soils (Figure 2) (Rana and Kalaichelvan, 2013