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When voltage-dependent calcium channels are opened by the closure of ATP-sensitive potassium channels, the intracellular calcium ion concentration rises, and insulin production is stimulated

Gnesin S, Vontobel P, Munk S, et al

After searching the available literature, we determined that 13 of our target candidates (Figure 3A) had previously been reported to be affected by exercise, whereas nine target candidates (Figure 3B) with known biological actions have not been previously reported to be altered by exercise