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In the later stages of bipolar disorder, an imbalance between inflammatory cytokines (especially TNF-alpha), mediators of oxidative stress, and BDNF persists even between episodes and is associated with metabolic disruption, progression of structural brain changes, and neurocognitive decline (85, 215, 231, 235)

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Correlation between low temperature adaptation and oxidative stress in Saccharomyces cerevisiae

& Woodbury-Smith, M

Early Onset of Disc Degeneration in SM/J Mice Is Associated with Changes in Ion Transport Systems and Fibrotic Events