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Pretreatment of animals with coenzyme Q 10 has been found to preserve myocardial function following ischemia-reperfusion injury by increasing ATP concentration, enhancing antioxidant capacity and limiting oxidative damage, regulating autophagy, and reducing cardiomyocyte apoptosis (37)

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Clinical evidence also highlights the link between L2HGDH impairment and antioxidant systems

Therefore, taken together, these limitations reflect the need for developing a more accessible and simpler assay that can measure the rate of NADPH consumption by a specific pathway, such as the one mediated by glutathione-disulfide reductase (GSR)

2 Pharmacological mechanisms and pathways of curcumin Curcumin is often described as a pleiotropic molecule because of its ability to interact with multiple cellular targets and signaling pathways