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But, they require GSH which may become compromised by oxidative stress induced by several factors in the course of serious infections, such as oxidative bursts by activated macrophages, hypergeneration of superoxide, TNFa-generated oxidative stress, induction of Cox-2 with increased arachidonate oxidations, and induction of iNOS with increased formation of nitric oxides and nitrosated GSH

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At specified time points (Day 0, 2, 3, or 5 post-inoculation), bronchoalveolar lavage was performed as previously described ( 2.5 Lung histology Mouse lungs assigned for histology were isolated and inflated with 1 ml of 4% paraformaldehyde in PBS for fixation

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