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Furthermore, the cholesterol-metabolizing enzyme cholesterol 25-hydroxylase (CH25H) and its product, 25-hydroxycholesterol, regulate activating transcription factor 3 (ATF3) expression to promote tight junction protein production and protect the intestinal barrier [390]

Liver, for example, is so nutrient-dense that a single portion once or twice a week is sufficient for most people

(2024) recently discovered that guanidine, produced by Bacteroides vulgatus, although a microbial metabolite, has a mechanism of action that is completely different from that of TMAO

A landmark randomized, double-blind, placebo-controlled trial published in Obstetrics and Gynecology found that vitamin B6 at 25 mg every eight hours significantly reduced nausea severity compared to placebo