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Its pharmacological activators, including oltipraz and bardoxolone methyl, have been shown to ameliorate cognitive deficits and attenuate lipid peroxidation damage in AD models (Chu et al., 2024)

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However, Nrf2 is the drug target of dimethylfumarate (DMF), which has already been approved for psoriasis and MS, both diseases in which oxidative stress plays a major role

(2015)., Streptozotocin-induced type-1-diabetes disease onset in sprague-dawley rats is associated with an altered intestinal microbiota composition and decreased diversity., Microbiology (Reading, England), 161(Pt 1), 182-193