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Abstract Parkinsons disease (PD) is a common neurodegenerative disorder caused by a spread of misfolded -synuclein and ascending neuronal degeneration mainly in dopaminergic neurons, leading to progressive nigrostriatal dysfunction and disruption of other pathways

To this end, the Pmc4 mediator subunit was fused to a degron, and we found that IAA17 in combination with the two F-box proteins atAFB2 and osTIR1 was most effective (Supplementary Fig

This deficiency creates a cycle: low glutathione leads to more oxidative stress, which leads to more skin reactivity, which further depletes glutathione

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