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Constructing non-human primate models with CRISPR Cas9 and spin-off gene editing technologies is a trend in studying the neural system PD in the brain, but the high cost of materials, long breeding cycles, and difficulty of gene editing operations make it difficult to form large-scale studies like mice

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Glutathione is more quickly and effectively absorbed into the bloodstream when given via IV, which avoids the GI tract

Importantly, the authors also showed that Slc39a8 localizes to the apical membrane of cholangiocytes and recovers Mn from bile, thereby reducing Mn excretion and maintaining systemic Mn storage 16

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