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Highest concentrations were determined for caffeic acid, besides ferulic acid, catechin, 5-(3,4-dihydroxyphenyl)--valerolactone, and taxifolin (Table 2)

We hypothesize that the observed improvement in CKD progression may be related to the stronger glycemic control achieved by this combination, coupled with complementary molecular, pharmacokinetic, and pharmacodynamic mechanisms

More specifically, the prominent role of Nrf2 pathway in oxidative stress handling throughout life is further emphasized by the fact that the inhibition of this pathway by progerin has been incriminated in the premature aging occurring during progeria disease (Silva-Palacios et al., 2016)