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An in vitro study using a pancreatic beta cell line showed that tacrolimus treatment increased apoptosis and the production of mitochondrial reactive oxygen species, while cotreatment with coenzyme Q 10 effectively attenuated these alterations

Drug-induced thrombocytopenia: pathogenesis, evaluation, and management

Hu, Q., Li, H., Wang, L., Gu, H

In the presence of ROS, thiols are initially oxidized into S-sulfenic acids (SOH), which are highly reactive and can be converted into more stable forms, including S-sulfinic acids (SO 2 H) and disulfides (SS) (Fig