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Permanent opening of the mPTP results in mitochondrial depolarization, inhibition of respiration, cessation of ATP synthesis, mobilization of cytochrome C, and apoptosis 43

Although the integrity of the cell membrane is lost during ferroptosis, it does not cause cell swelling [8]

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Ramonet D., Perier C., Recasens A., et al., Optic Atrophy 1 Mediates Mitochondria Remodeling and Dopaminergic Neurodegeneration Linked to Complex I Deficiency, Cell Death and Differentiation 20, no

Bioavailability is a measure of how much of a substance actually enters systemic circulation and is available to have an active effect