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Best Pract Res Clin Gastroenterol 27(4):577596 Valente MJ et al (2012) Contribution of oxidative metabolism to cocaine-induced liver and kidney damage

Biotin depletion exacerbated neurotoxicity in flies lacking the enzyme biotinidase, whereas biotin supplementation reversed Mn-induced pathology in wild-type flies, revealing the therapeutic potential of using biotin to treat Parkinsonism phenotypes

In some embodiments, preparation of certain cations of Formulas I and IA may occur by alkylating the N-positions of the quinoline scaffold using, for example, iodomethane or methyl trifluoromethanesulfonate (see Scheme 1)