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Ensuring patient safety, we conduct a kidney function test before administering the treatment, as it may pose risks for those with impaired kidney function

Therefore, the signaling pathway mediated by 3-HKA activation of metabolic glutamate receptor 4(mGluR4) that promotes the conversion of astrocytes to the neuroprotective A2 phenotype and ultimately induces angiogenesis, and the neuroprotective effects provided by KYNA through antagonizing NMDAR and exerting antioxidant effects, synergistically constitute a dual neurovascular protective mechanism

Taking tablets with food can minimize these effects

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To test this hypothesis, we created double knockout mice that lacked one or both copies of p53 and Rlip