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Data availability The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier PXD05530

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In macrophages, for example, lactylation of proteins such as Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta (IB) enhances their stability or transcriptional co-activator capacity, thereby boosting the production of cytokines like IL-6 and IL-12 (58)