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Conclusion The main pathophysiological mechanisms contributing to the development of cardiovascular and cerebrovascular diseases involve NAD + metabolism, immune regulation, oxidative stress, and calcium ion concentration, all of which are linked to the role of CD38

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This balanced interplay of upregulated and downregulated proteins, including the proteasome complex, highlights the intricate regulatory networks that underpin neuronal stability, adaptability, and intercellular communication within the model, emphasizing their vital roles in maintaining the overall health and functionality of the nervous system