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retatrutide in Phase III Metabolic focus: Obesity, overweight, type 2 diabetes, sleep apnea, osteoarthritis, MASLD/MASH and cardiovascular/renal outcomes Eli Lillys obesity portfolio includes Zepbound, the newly approved oral GLP-1 drug Foundayo and the Phase III candidate retatrutide

In addition to its effects on insulin, GIP plays a crucial role in fat accumulation by promoting the activity of adipocyte-expressed lipoprotein lipase and promoting bone formation by preventing osteoclast apoptosis, as evidenced by the thinner bone trabeculae seen in mice lacking GIP receptors [20,21,22]