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Tirzepatide carries an FDA boxed warning for thyroid C-cell tumors plus warnings for pancreatitis, gallbladder disease, and hypoglycemia with insulin secretagogues

[4] In the SURMOUNT-1 obesity trial, a 72-week placebo-controlled study in 2,539 adults with obesity (without diabetes), mean weight change was 15.0%, 19.5%, and 20.9% at the 5, 10, and 15 mg doses versus 3.1% for placebo