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In contrast, p53-deficient cells fail to mount this adaptive response, resulting in ROS accumulation, impaired proliferation, and reduced tumor growth in vivo [159, 160]

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The KD is gaining attention as a low-cost, minimally toxic, and easily implementable nutritional intervention with biologically plausible anticancer mechanisms including metabolic targeting, anti-inflammatory effects, epigenetic modulation, and microenvironmental remodeling