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Incidence rates for BN development were calculated

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[7] A wide range of toxicants such as chemicals, antibiotics, steroidal and non-steroidal drugs, viral infections, dietary and herbal supplements contribute to the onset of liver disease by triggering oxidative stress. It plays a vital role in the pathogenesis and progression of hepatotoxicity by modulating the release of inflammatory mediators such as TNF-, IL-1, and apoptotic factors (Bax, Bcl-2, caspase-3, 9, etc)