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The dosage of AOD9604 used in this study or 0.25 mg per injection, was carefully calculated to be molar equivalent to doses of full-length GH shown to be effective in prior rabbit OA studies

Sci Rep 15 , 39026 (2025)

Longevity pathway activation NAD+ plays a crucial role in activating sirtuins, a family of proteins involved in cellular repair, stress response, and aging