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Abstract Glutathione-mediated biotransformation in the liver is a well-known detoxification process to eliminate small xenobiotics, but its impacts on nanoparticle retention, targeting and clearance are much less understood than liver macrophage uptake, even though both processes are involved in liver detoxification

6.1 PD-specific features of oxidative stress 6.1.1 Dopamine oxidation and quinone stress Contemporary syntheses reinforce that dopamine auto-oxidation generates reactive o-quinones and H 2 O 2 that selectively injure substantia nigra neurons through protein modification, mitochondrial compromise, and redox cycling

E.TognoliniM.BorgesG.CrozierA

These inhibitors are being investigated as potential therapeutic agents for various diseases, including cancer, Alzheimers disease, and type 2 diabetes [262]