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It is an alteration in the balance of prooxidant /antioxidant system in favour of prooxidant with attendant lethal effects with resultant damage to the cellular macromolecules (Fig

It is less irritating than salicylic acid due to its large molecule size

30,31 This process allows the cancer cells to survive in relatively nutrient-poor environments, taking up a number of different macromolecules derived from both the periphery (probably accumulating in oedema) and necrotic areas of the tumour

In addition, E3 ligases anaphase-promoting complex subunit 2 (ANAPC2) promotes KRAS degradation through the ubiquitinproteasome pathway in colorectal cancer [179]