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Owing to the involvement of Gln in GSH synthesis, we detected changes in intracellular GSH and reactive oxygen species (ROS)

The evolution of GSH in aging fibroblasts showed a sudden increase in its concentration just before cell death, whereas GPx activity was already decreasing at the beginning of passages, and that of glutathione reductase was constant and reaching a very low level at the end of the cell culture, suggesting that the GSH system was probably involved in cell degeneration associated with aging [18]

(2016) MicroRNA-433 inhibits migration and invasion of ovarian cancer cells via targeting Notch1, Neoplasma , 63 , 696-704, doi: Li, H., Li, J., Yang, T., Lin, S., and Li, H