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Therefore, the deficiency of SIRT5 expression resulted in diminished resistance of cardiomyocytes to HG-induced cellular injury, further exacerbating DCM-associated myocardial injury

Moreover, recent clinical studies have shown that HCM-causative FHOD3 mutations increase the risk of cardiovascular death and all-cause death, with the onset of the disease occurring as early as age 4 and as late as age 63 (Vodnjov et al., 2023

10.13862/j.cn43-1446/r.2024.06.024 Guid J Trad Chin Med Pharm

These genes encode synaptic-plasticity-related proteins (neurogranin and neuromodulin) and neurotransmission-regulating synaptic proteins (postsynaptic density protein 95 and synaptopodin), which are involved in learning and memory functions and are downregulated in response to oxidative stress and inflammation 47,48