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Metformin activation of AMPK-dependent pathways is neuroprotective in human neural stem cells against Amyloid-beta-induced mitochondrial dysfunction

The standard dose is 1000 mcg, given as an intramuscular or subcutaneous injection

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Further investigation into this area may also explain why specific neuronal populations (e.g., striatal medium spiny neurons) are particularly vulnerable in neurodegenerative or neuropsychiatric disorders based on trafficking defects

The findings reveal intricate, differential effects of the sweeteners across behavioral paradigms and biochemical analyses, offering crucial insights into their safety and potential neurotoxicity