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Levine ME, Suarez JA, Brandhorst S et al (2014) Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population

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Additionally, in order to understand the complex relationship between cancer cells and the TME, more research needs to focus on the cancer cells themselves, including looking at patient-derived multi-cell populations which, due to the heterogeneity of cancers, would be necessary to obtain more clinically relevant data

Excessive production of acetyl-CoA by -oxidation and/or depletion of oxalacetate are both capable of triggering liver ketogenesis