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Under low-iron conditions, IRPs bind to IREs in the untranslated regions (UTRs) of target mRNAs, stabilizing TfR1 and DMT1 transcripts while suppressing translation of ferritin and FPN1

However, disruptions in mitochondrial quality control are crucial in COPD onset and progression, regardless of aetiology

This apparent rise in HHcy prevalence underscores the need for in-depth investigation of the molecular mechanisms underlying its pathophysiological effects, particularly given the growing number of associations reported between HHcy and human disease

Hearn TJ, Coleman AE, Lai JC, et al

One human mutation encodes the same Akita substitution (Cys A7 Tyr) as in the Ins2 gene of the Mody4 mouse