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Complement fixation and generation of the membrane attack complex result in damage to AChR and voltage gated sodium channels in the post-synaptic membrane which reduces the safety factor and increases the threshold for excitation (Fig

443, luglio 2005 Steiber, A

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Glutathione is often referred to as the bodys master antioxidant, and for good reason since this plays a crucial role in neutralizing free radicals these are pesky unstable molecules that can damage our cells and DNA

It again implicates ChaC1-mediated GSH depletion as a mechanism underlying AURs cytotoxic efficacy at elevated concentrations